Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

All proteins undergo proteolysis and the regulation of these processes is a critical issue for cell sig­na­ling and tissue ho­meo­sta­sis. Although proteolysis is required for protein disposal and the re­gu­la­tion of the lifespan of proteins, an addi­tio­nal major function of protein cleavage is the or­ches­tra­tion of many signaling pathways. The functions of proteases are essential in many physiological pro­ces­ses, including development, blood coagulation, and cell death. Dysregulation of proteolytic events is as­so­ci­at­ed with the onset of many diseases and pathophysiologic conditions such as inflammation, neu­ro­de­ge­ne­ra­tion, cancer and infectious diseases.

Project overview

Template by OS Templates