Collaborative Research Centre 877

Proteolysis as a Regulatory Event in Pathophysiology

Christian-Albrechts-Universität zu Kiel

Education and Academic Positions
2007 Habilitation in Biochemistry, University of Kiel
2001 PhD in Cell Biology, Institute of Anatomy, University of Kiel
1998-1999 Diploma thesis, Leibniz-Center for Medicine and Biosciences, Borstel
1994-1999 Studies of Biology, University of Kiel
Research Experience
2008 W2 Professor, Department of Dermatology and Allergology, University of Kiel
2006-2008 Junior Professorship, Biochemical Institute, University of Kiel
2002-2006 Scientific Assistant, Biochemical Institute, University of Kiel
2001-2002 Research Associate, Institute of Anatomy, University of Kiel
1999-2001 PhD student, Institute of Anatomy, University of Kiel
Awards and Honors
2009 W.H. Hauss Award of the German Atherosclerosis Society
2006 Biochemical Science Award, Ferring Pharmaceuticals
List of 5 Selected Publications
1. Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K (2016) Phosphatidylserine exposure is required for ADAM17 sheddase function. Nat Commun 7: 11523
2. Sommer A, Fries A, Cornelsen I, Speck N, Koch-Nolte F, Gimpl G, Andrä J, Bhakdi S, Reiss K (2012) Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation. J Biol Chem 287: 23678-89
3. Maretzky T*, Evers A*, Zhou W, Swendeman SL, Wong PM, Rafii S, Reiss K, Blobel CP (2011) Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. Nat Commun 2: 229
4. Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel CP, Saftig P, Reiss K (2008) ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin. Circ Res 102: 1192-1201
5. Reiss K*, Maretzky T*, Ludwig A, Tousseyn T, De Strooper B, Hartmann D, Saftig P (2005) ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signaling. EMBO J 24: 742-752