We are interested in secondary metabolite genes encoded by fungi of marine origin.
To this end we have already sequenced several fungal genomes from marine isolates.
Marine fungi provide a fresh source of previously uncharacterized secondary metabolites.
Currently we work on fungi we isolated from sediment of the Baltic Sea and the Mid-Atlantic Ridge.
KUMAR A, SORENSEN JL, HANSEN FT, ARVAS M, SYED MF, HASSAN L, BENZ JP, RECORD E HENRISSAT B, PÃ–GGELER S, KEMPKEN F (2018) Genome sequencing and analyses of two marine fungi from the North Sea unravels a plethora of novel biosynthetic gene clusters. Sci Rep 8:10187. doi: 10.1038/s41598-018-28473-z. Abstract
KUMAR A, HENRISSAT B, ARVAS M, SYED MF, THIEME N, BENZ JP, SORENSEN JL, RECORD E, KEMPKEN F (2015) De novo assembly and genome analyses of the marine-derived Scopulariopsis brevicaulis strain LF580 unravels life-style traits and anticancerous scopularide biosynthetic gene cluster. PLoS ONE 10:e0140398. doi: 10.1371/journal.pone.0140398
LUKASSEN MB, SAEI W, SONDERGAARD TE, TAMMINEN A, KUMAR A, KEMPKEN F, WIEBE MG, SORENSEN JL (2015) Identification and overexpression of the scopularide biosynthetic gene cluster in Scopulariopsis brevicaulis. Mar Drugs 13: 4331-4343 doi:10.3390/md13074331
KRAMER A, PAUN L, KEMPKEN F, IMHOFF JF, LABES A (2014) Development and validation of a fast and optimized screening method for enhanced production of secondary metabolites using the marine Scopulariopsis brevicaulis strain LF580 producing anti-cancer active scopularide A and B, PLoS ONE 9:e103320. doi: 10.1371/journal.pone.0103320
Fungal isolates from Baltic Sea