CAU Logo
Christian–Albrechts–Universität zu Kiel
Institut für Medizinische Informatik und Statistik
Logo
english

Publikationen von Silke Szymczak



Tsoi LC, Rodriguez E, Degenhardt F, Baurecht H, Wehkamp U, Volks N, Szymczak S, Swindell WR, Sarkar MK, Raja K, Shao S, Patrick M, Gao Y, Uppala R, Perez White BE, Getsios S, Harms PW, Maverakis E, Elder JT, Franke A, Gudjonsson JE, Weidinger S.
Atopic dermatitis is an IL-13 dominant disease with greater molecular heterogeneity compared to psoriasis.
J Invest Dermatol, (2019).  [abstract]

Nikolaus S, Waetzig GH, Butzin S, Ziolkiewicz M, Al-Massad N, Thieme F, Lövgren U, Rasmussen BB, Reinheimer TM, Seegert D, Rosenstiel P, Szymczak S, Schreiber S.
Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases.
Int J Colorectal Dis, 33 (2018), 927-936.  [abstract]

Kachroo P, Szymczak S, Heinsen FA, Forster M, Bethune J, Hemmrich-Stanisak G, Baker L, Schrappe M, Stanulla M, Franke A.
NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia.
Epigenomics, 10 (2018), 133-147.  [abstract]

von Schönfels W, Beckmann JH, Ahrens M, Hendricks A, Röcken C, Szymczak S, Hampe J, Schafmayer C.
Histologic improvement of NAFLD in patients with obesity after bariatric surgery based on standardized NAS (NAFLD activity score).
Surg Obes Relat Dis, 14 (2018), 1607-1616.  [abstract]

Chen W, Hopfner F, Szymczak S, Granert O, Müller SH, Kuhlenbäumer G, Deuschl G.
Topography of essential tremor.
Parkinsonism Relat Disord, 40 (2017), 58-63.  [abstract]

Degenhardt F, Seifert S, Szymczak S.
Evaluation of variable selection methods for random forests and omics data sets.
Brief Bioinform, (2017).  [abstract]

Nikolaus S, Schulte B, Al-Massad N, Thieme F, Schulte DM, Bethge J, Rehman A, Tran F, Aden K, Häsler R, Moll N, Schütze G, Schwarz MJ, Waetzig GH, Rosenstiel P, Krawczak M, Szymczak S, Schreiber S.
Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases.
Gastroenterology, 153 (2017), 1504-1516.e2.  [abstract]

Wang J, Thingholm LB, Skiecevičienė J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Rühlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan WH, Sheibani-Tezerji R, Häsler R, Rosenstiel P, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall HU, Lieb W, Nöthlings U, Karlsen TH, Baines JF, Franke A.
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
Nat Genet, (2016).  [abstract]

Tschurtschenthaler M, Kachroo P, Heinsen FA, Adolph TE, Rühlemann MC, Klughammer J, Offner FA, Ammerpohl O, Krueger F, Smallwood S, Szymczak S, Kaser A, Franke A.
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
Sci Rep, 6 (2016), 31640.  [abstract]

Szymczak S, Holzinger E, Dasgupta A, Malley JD, Molloy AM, Mills JL, Brody LC, Stambolian D, Bailey-Wilson JE.
r2VIM: A new variable selection method for random forests in genome-wide association studies.
BioData Min, 9 (2016), 7.  [abstract]

Degenhardt F, Niklowitz P, Szymczak S, Jacobs G, Lieb W, Menke T, Laudes M, Esko T, Weidinger S, Franke A, Döring F, Onur S.
Genome-wide association study of serum coenzyme Q10 levels identifies susceptibility loci linked to neuronal diseases.
Hum Mol Genet, (2016).  [abstract]

Degenhardt F, Dirmeier A, Lopez R, Lang S, Kunst C, Roggenbuck D, Reinhold D, Szymczak S, Rogler G, Klebl F, Franke A, Rieder F.
Serologic Anti-GP2 Antibodies Are Associated with Genetic Polymorphisms, Fibrostenosis, and Need for Surgical Resection in Crohn's Disease.
Inflamm Bowel Dis, 22 (2016), 2648-2657.  [abstract]

Holzinger ER, Szymczak S, Malley J, Pugh EW, Ling H, Griffith S, Zhang P, Li Q, Cropp CD, Bailey-Wilson JE.
Comparison of parametric and machine methods for variable selection in simulated Genetic Analysis Workshop 19 data.
BMC Proc, 10 (2016), 147-152.  [abstract]

Hübenthal M, Hemmrich-Stanisak G, Degenhardt F, Szymczak S, Du Z, Elsharawy A, Keller A, Schreiber S, Franke A.
Sparse Modeling Reveals miRNA Signatures for Diagnostics of Inflammatory Bowel Disease.
PLoS One, 10 (2015), e0140155.  [abstract]

Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Mateo Leach I, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li H, Mok ZY, Nakatochi M, Sapari NS, Saxena R, Stewart AF, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Da Silva Couto Alves A, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Lyytikäinen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Bryan MS, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang Y, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu D, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husemoen LL, Hwang JY, Ichihara S, Igase M, Isono M, Justesen JM, Katsuya T, Kibriya MG, Kim YJ, Kishimoto M, Koh WP, Kohara K, Kumari M, Kwek K, Lee NR, Lee J, Liao J, Lieb W, Liewald DC, Matsubara T, Matsushita Y, Meitinger T, Mihailov E, Milani L, Mills R, Mononen N, Müller-Nurasyid M, Nabika T, Nakashima E, Ng HK, Nikus K, Nutile T, Ohkubo T, Ohnaka K, Parish S, Paternoster L, Peng H, Peters A, Pham ST, Pinidiyapathirage MJ, Rahman M, Rakugi H, Rolandsson O, Rozario MA, Ruggiero D, Sala CF, Sarju R, Shimokawa K, Snieder H, Sparsø T, Spiering W, Starr JM, Stott DJ, Stram DO, Sugiyama T, Szymczak S, Tang WH, Tong L, Trompet S, Turjanmaa V, Ueshima H, Uitterlinden AG, Umemura S, Vaarasmaki M, van Dam RM, van Gilst WH, van Veldhuisen DJ, Viikari JS, Waldenberger M, Wang Y, Wang A, Wilson R, Wong TY, Xiang YB, Yamaguchi S, Ye X, Young RD, Young TL, Yuan JM, Zhou X, Asselbergs FW, Ciullo M, Clarke R, Deloukas P, Franke A, Franks PW, Franks S, Friedlander Y, Gross MD, Guo Z, Hansen T, Jarvelin MR, Jørgensen T, Jukema JW, Kähönen M, Kajio H, Kivimaki M, Lee JY, Lehtimäki T, Linneberg A, Miki T, Pedersen O, Samani NJ, Sørensen TI, Takayanagi R, Toniolo D, , , , , Ahsan H, Allayee H, Chen YT, Danesh J, Deary IJ, Franco OH, Franke L, Heijman BT, Holbrook JD, Isaacs A, Kim BJ, Lin X, Liu J, März W, Metspalu A, Mohlke KL, Sanghera DK, Shu XO, van Meurs JB, Vithana E, Wickremasinghe AR, Wijmenga C, Wolffenbuttel BH, Yokota M, Zheng W, Zhu D, Vineis P, Kyrtopoulos SA, Kleinjans JC, McCarthy MI, Soong R, Gieger C, Scott J, Teo YY, He J, Elliott P, Tai ES, van der Harst P, Kooner JS, Chambers JC.
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Nat Genet, 47 (2015), 1282-93.  [abstract]

Holzinger ER, Szymczak S, Dasgupta A, Malley J, Li Q, Bailey-Wilson JE.
Variable selection method for the identification of epistatic models.
Pac Symp Biocomput, (2015), 195-206.  [abstract]

Gemoll T, Epping F, Heinrich L, Fritzsche B, Roblick UJ, Szymczak S, Hartwig S, Depping R, Bruch HP, Thorns C, Lehr S, Paech A, Habermann JK.
Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies.
Oncotarget, 6 (2015), 16517-26.  [abstract]

Forster M, Szymczak S, Ellinghaus D, Hemmrich G, Rühlemann M, Kraemer L, Mucha S, Wienbrandt L, Stanulla M, , Franke A.
Vy-PER: eliminating false positive detection of virus integration events in next generation sequencing data.
Sci Rep, 5 (2015), 11534.  [abstract]

Sei Y, Zhao X, Forbes J, Szymczak S, Li Q, Trivedi A, Voellinger M, Joy G, Feng J, Whatley M, Jones MS, Harper UL, Marx SJ, Venkatesan AM, Chandrasekharappa SC, Raffeld M, Quezado MM, Louie A, Chen CC, Lim RM, Agarwala R, Schäffer AA, Hughes MS, Bailey-Wilson JE, Wank SA.
A Hereditary Form of Small Intestinal Carcinoid Associated With a Germline Mutation in Inositol Polyphosphate Multikinase.
Gastroenterology, 149 (2015), 67-78.  [abstract]

Reuther S, Szymczak S, Raabe A, Borgmann K, Ziegler A, Petersen C, Dikomey E, Hoeller U.
Association between SNPs in defined functional pathways and risk of early or late toxicity as well as individual radiosensitivity.
Strahlenther Onkol, (2014).  [abstract]

Szymczak S, Simpson CL, Cropp CD, Bailey-Wilson JE.
False-positive rates in two-point parametric linkage analysis.
BMC Proc, 8 (2014), S110.  [abstract]

Bureau A, Parker MM, Ruczinski I, Taub MA, Marazita ML, Murray JC, Mangold E, Noethen MM, Ludwig KU, Hetmanski JB, Bailey-Wilson JE, Cropp CD, Li Q, Szymczak S, Albacha-Hejazi H, Alqosayer K, Field LL, Wu-Chou YH, Doheny KF, Ling H, Scott AF, Beaty TH.
Whole Exome Sequencing of Distant Relatives in Multiplex Families Implicates Rare Variants in Candidate Genes for Oral Clefts.
Genetics, 197 (2014), 1039-1044.  [abstract]

Dasgupta A, Szymczak S, Moore JH, Bailey-Wilson JE, Malley JD.
Risk estimation using probability machines.
BioData Min, 7 (2014), 2.  [abstract]

Schönherr M, Bhattacharya A, Kottek T, Szymczak S, Köberle M, Wickenhauser C, Siebolts U, Saalbach A, Koczan D, Magin TM, Simon JC, Kunz M.
Genomewide RNAi screen identifies protein kinase Cb and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis.
Pigment Cell Melanoma Res, 27 (2014), 418-30.  [abstract]

Szymczak S, Scheinhardt MO, Zeller T, Wild PS, Blankenberg S, Ziegler A.
Adaptive linear rank tests for eQTL studies.
Stat Med, 32 (2013), 524-37.  [abstract]

Gemoll T, Habermann JK, Becker S, Szymczak S, Upender MB, Bruch HP, Hellman U, Ried T, Auer G, Jörnvall H, Roblick UJ.
Chromosomal aneuploidy affects the global proteome equilibrium of colorectal cancer cells.
Anal Cell Pathol (Amst), 36 (2013), 149-61.  [abstract]

Raabe A, Derda K, Reuther S, Szymczak S, Borgmann K, Hoeller U, Ziegler A, Petersen C, Dikomey E.
Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy.
Radiat Oncol, 7 (2012), 65.  [abstract]

Gemoll T, Habermann JK, Lahmann J, Szymczak S, Lundgren C, Bündgen NK, Jungbluth T, Nordström B, Becker S, Lomnytska MI, Bruch HP, Ziegler A, Hellman U, Auer G, Roblick UJ, Jörnvall H.
Protein profiling of genomic instability in endometrial cancer.
Cell Mol Life Sci, 69 (2012), 325-33.  [abstract]

Thorns C, Kuba J, Bernard V, Senft A, Szymczak S, Feller AC, Bernd HW.
Deregulation of a distinct set of microRNAs is associated with transformation of gastritis into MALT lymphoma.
Virchows Arch, 460 (2012), 371-7.  [abstract]

Wild PS, Zeller T, Schillert A, Szymczak S, Sinning CR, Deiseroth A, Schnabel RB, Lubos E, Keller T, Eleftheriadis MS, Bickel C, Rupprecht HJ, Wilde S, Rossmann H, Diemert P, Cupples LA, Perret C, Erdmann J, Stark K, Kleber ME, Epstein SE, Voight BF, Kuulasmaa K, Li M, Schäfer AS, Klopp N, Braund PS, Sager HB, Demissie S, Proust C, König IR, Wichmann HE, Reinhard W, Hoffmann MM, Virtamo J, Burnett MS, Siscovick D, Wiklund PG, Qu L, El Mokthari NE, Thompson JR, Peters A, Smith AV, Yon E, Baumert J, Hengstenberg C, März W, Amouyel P, Devaney J, Schwartz SM, Saarela O, Mehta NN, Rubin D, Silander K, Hall AS, Ferrieres J, Harris TB, Melander O, Kee F, Hakonarson H, Schrezenmeir J, Gudnason V, Elosua R, Arveiler D, Evans A, Rader DJ, Illig T, Schreiber S, Bis JC, Altshuler D, Kavousi M, Witteman JC, Uitterlinden AG, Hofman A, Folsom AR, Barbalic M, Boerwinkle E, Kathiresan S, Reilly MP, Samani NJ, Schunkert H, Cambien F, Lackner KJ, Tiret L, Salomaa V, Munzel T, Ziegler A, Blankenberg S.
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.
Circ Cardiovasc Genet, 4 (2011), 403-12.  [abstract]

Gemoll T, Roblick UJ, Szymczak S, Braunschweig T, Becker S, Igl BW, Bruch HP, Ziegler A, Hellman U, Difilippantonio MJ, Ried T, Jörnvall H, Auer G, Habermann JK.
HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers.
Cell Mol Life Sci, 68 (2011), 3261-74.  [abstract]

Rotival M, Zeller T, Wild PS, Maouche S, Szymczak S, Schillert A, Castagné R, Deiseroth A, Proust C, Brocheton J, Godefroy T, Perret C, Germain M, Eleftheriadis M, Sinning CR, Schnabel RB, Lubos E, Lackner KJ, Rossmann H, Münzel T, Rendon A, , Erdmann J, Deloukas P, Hengstenberg C, Diemert P, Montalescot G, Ouwehand WH, Samani NJ, Schunkert H, Tregouet DA, Ziegler A, Goodall AH, Cambien F, Tiret L, Blankenberg S.
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans.
PLoS Genet, 7 (2011), e1002367.  [abstract]

Castagné R, Zeller T, Rotival M, Szymczak S, Truong V, Schillert A, Trégouët DA, Münzel T, Ziegler A, Cambien F, Blankenberg S, Tiret L.
Influence of sex and genetic variability on expression of X-linked genes in human monocytes.
Genomics, 98 (2011), 320-6.  [abstract]

Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley SR, Bauerfeind A, Hummel O, Lee YA, Paskas S, Rintisch C, Saar K, Cooper J, Buchan R, Gray EE, Cyster JG, , Erdmann J, Hengstenberg C, Maouche S, Ouwehand WH, Rice CM, Samani NJ, Schunkert H, Goodall AH, Schulz H, Roider HG, Vingron M, Blankenberg S, Münzel T, Zeller T, Szymczak S, Ziegler A, Tiret L, Smyth DJ, Pravenec M, Aitman TJ, Cambien F, Clayton D, Todd JA, Hubner N, Cook SA.
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Nature, 467 (2010), 460-4.  [abstract]

Borgmann K, Raabe A, Reuther S, Szymczak S, Schlomm T, Isbarn H, Gomolka M, Busjahn A, Bonin M, Ziegler A, Dikomey E.
The potential role of G2- but not of G0-radiosensitivity for predisposition of prostate cancer.
Radiother Oncol, 96 (2010), 19-24.  [abstract]

Zschenker O, Raabe A, Boeckelmann IK, Borstelmann S, Szymczak S, Wellek S, Rades D, Hoeller U, Ziegler A, Dikomey E, Borgmann K.
Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity.
Radiother Oncol, 97 (2010), 26-32.  [abstract]

Müller H, Kröger J, Jöhren O, Szymczak S, Bader M, Dominiak P, Raasch W.
Stress sensitivity is increased in transgenic rats with low brain angiotensinogen.
J Endocrinol, 204 (2010), 85-92.  [abstract]

Zeller T, Wild P, Szymczak S, Rotival M, Schillert A, Castagne R, Maouche S, Germain M, Lackner K, Rossmann H, Eleftheriadis M, Sinning CR, Schnabel RB, Lubos E, Mennerich D, Rust W, Perret C, Proust C, Nicaud V, Loscalzo J, Hübner N, Tregouet D, Münzel T, Ziegler A, Tiret L, Blankenberg S, Cambien F.
Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
PLoS One, 5 (2010), e10693.  [abstract]

Schwarz DF, Szymczak S, Ziegler A, König IR.
Evaluation of single-nucleotide polymorphism imputation using random forests.
BMC Proc, 3 Suppl 7 (2009), S65.  [abstract]

Cupples LA, Beyene J, Bickeböller H, Daw EW, Fallin MD, Gauderman WJ, Ghosh S, Goode EL, Hauser ER, Hinrichs A, Kent JW, Martin LJ, Martinez M, Neuman RJ, Province M, Szymczak S, Wilcox MA, Ziegler A, Maccluer JW, Almasy L.
Genetic Analysis Workshop 16: Strategies for genome-wide association study analyses.
BMC Proc, 3 Suppl 7 (2009), S1. 

Schillert A, Schwarz DF, Vens M, Szymczak S, König IR, Ziegler A.
ACPA: automated cluster plot analysis of genotype data.
BMC Proc, 3 Suppl 7 (2009), S58.  [abstract]

Szymczak S, Igl BW, Ziegler A.
Detecting SNP-expression associations: a comparison of mutual information and median test with standard statistical approaches.
Stat Med, 28 (2009), 3581-96.  [abstract]

Szymczak S, Biernacka JM, Cordell HJ, González-Recio O, König IR, Zhang H, Sun YV.
Machine learning in genome-wide association studies.
Genet Epidemiol, 33 Suppl 1 (2009), S51-7.  [abstract]

Pobigaylo N, Szymczak S, Nattkemper TW, Becker A.
Identification of genes relevant to symbiosis and competitiveness in Sinorhizobium meliloti using signature-tagged mutants.
Mol Plant Microbe Interact, 21 (2008), 219-31.  [abstract]

Borgmann K, Hoeller U, Nowack S, Bernhard M, Röper B, Brackrock S, Petersen C, Szymczak S, Ziegler A, Feyer P, Alberti W, Dikomey E.
Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy.
Int J Radiat Oncol Biol Phys, 71 (2008), 256-64.  [abstract]

Szymczak S, Nuzzo A, Fuchsberger C, Schwarz DF, Ziegler A, Bellazzi R, Igl BW.
Genetic association studies for gene expressions: permutation-based mutual information in a comparison with standard ANOVA and as a novel approach for feature selection.
BMC Proc, 1 Suppl 1 (2007), S9.  [abstract]

Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, .
Genomewide association analysis of coronary artery disease.
N Engl J Med, 357 (2007), 443-53.  [abstract]

Chen GK, Zheng T, Witte JS, Goode EL, Gao L, Hu P, Suh YJ, Suktitipat B, Szymczak S, Woo JH, Zhang W.
Genome-wide association analyses of expression phenotypes.
Genet Epidemiol, 31 Suppl 1 (2007), S7-S11.  [abstract]

Schwarz DF, Szymczak S, Ziegler A, König IR.
Picking single-nucleotide polymorphisms in forests.
BMC Proc, 1 Suppl 1 (2007), S59.  [abstract]

Pobigaylo N, Wetter D, Szymczak S, Schiller U, Kurtz S, Meyer F, Nattkemper TW, Becker A.
Construction of a large signature-tagged mini-Tn5 transposon library and its application to mutagenesis of Sinorhizobium meliloti.
Appl Environ Microbiol, 72 (2006), 4329-37.  [abstract]